University of Plymouth

About this entry

 Dr Tina Joshi Lecturer in Molecular Microbiology at the University of Plymouth, teaching clinical microbiology and antibiotic stewardship at the Faculty of Medicine & Dentistry. Tina specialises in development of novel rapid point of care detection systems for antibiotic resistant bacteria and in infection control. Tina has over 10 years of experience in development of novel microwave enhanced rapid diagnostics for microbial detection.

By 2050 it is estimated that 10 million people world-wide will die as a result of being infected with drug- resistant bacteria (Lord Jim O’Neil, 2014). Bacteria which were previously susceptible to antibiotic treatment have evolved to develop resistance to commonly used antibiotics, rendering them ineffective to combat infection. Now there are fewer antibiotics available to treat patients with certain infections. Hence, there is a global drive not only to discover new antibiotics to combat these bacteria, but also to develop new types of diagnostics that can help diagnose infection at point of care. 

Tina's research focuses on designing low cost, rapid (5 minutes!), point of care nucleic acid-based biosensor assays for detection of AMR resistance genes and other pathogens that work within minutes from sample to result. This research is multidisciplinary and encompasses the Engineering, Biology, Informatics and Chemistry disciplines. 

Specifically the device utilizes precision microwave engineering to liberate bacterial/spore DNA for pathogen detection. Tina also designs label-free biosensor assays using bioinformatics in aptamer design and in collaboration with materials science to explore use of novel materials such as graphene within the assays. A key part of this research includes integration into a prototype point of care device ready for commercial uptake. 

 

If you would like to be introduced to this team for collaboration, get in touch with the Longitude prize.