University of Delhi South Campus - AMR Team
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The University of Delhi South Campus - AMR Team include qualified microbiologists, biotechnologists and bioinformatists. The team is currently involved in understanding the prevalence of AMR to beta-lactam antibiotics in India and comparative genomics approach to identify newer targets to inhibit beta-lactamases and inhibitor-resistant beta-lactamases.The team has also developed CBMAR - a comprehensive beta-lactamase molecular annotation resource for prospective investigators in this area of research.The team is also initiating work on the whole genome sequencing (WGS) approach to identify AMR and virulence profiles of pathogenic bacteria.Recent publications: 1. Singhal N, Srivastava A, Kumar M, Virdi JS (2015) PLoS One. Apr 28; 10(4):e0123564. Doi: 10.1371/journal.pone.01235642.Kumar R, Srivastava A, Kumari B, Kumar M (2015) J Theoretical Biol, 365, 96-103. doi:10.1016/j.jtbi.2014.10.0083. Singhal N, Kumar M and Virdi JS (2015) Indian J Med Microbiol (in press)4.Srivastava A, Singhal N, Goel M, Virdi JS, Kumar M (2014) Scientific World Journal, Article ID 980572 http://dx.doi.org/10.1155/2014/9805725.Singhal N, Kumar M, Virdi JS (2014) Scientific Reports (Nature Publishing Group) 4: 5270 | DOI: 10.1038/srep052706.Srivastava A, Singhal N, Goel M, Virdi JS, Kumar M (2014) Database (Oxford) doi: 10.1093/database/bau111
To develop an under 30 minutes test for detection of antimicrobial resistance in urinary tract infections (UTI), and to suggest the most appropriate antibiotics for treatment. The test intends to integrate two proven technologies - a microfluidics platform incorporating resistance-genes-array for detection of antibiotic resistance genes including mutation detection in the UTI urine sample, and an algorithm based selection of most appropriate antibiotics for treatment of the infection, such that unnecessary use of antibiotics is avoided. The whole hardware and the software are to be housed into a tablet format, which is portable,