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About this entry
MGM Central Research Laboratory, MGM Medical College and Hospital, MGMIHS is accelerating basic and applied research mainly in the area of drug discovery and molecular diagnostics. Our innovation revolves around the integration of advanced knowledge of protein science, gene science, enzymology, metabolic networks, natural products chemistry, green synthesis etc. Our laboratory is actively engaged in discovery and diagnostic research in the area of tuberculosis, malaria, obesity, diabetes etc. We have successfully synthesized several biogenic nanoparticles for highly sensitive diagnostics and therapeutic use. A protein-based bioreactor for the generation of fluorescent nanoparticles (quantum dots) is our major achievement.
Antibody-conjugated quantum dots have the potential to detect the antigen of Mycobacterium tuberculosis at a very low concentration. Our laboratory has successfully developed capability to conjugate antibodies with quantum dots, which display good florescence intensity. Beside peer-reviewed publications, we have already filed several patents. For this entry, our team would like to develop simple antibody-conjugated quantum dots based rapid kits for differentiation of LTB (latent tuberculosis) from active TB (tuberculosis).